NHS Evidence eng.nhs.uk https://sp-auth.nice.org.uk SP Auth SP Auth https://sp-auth.nice.org.uk/ data:image/png;base64,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 Public sp-auth.nice.org.uk MIIDbTCCAlWgAwIBAgIJAMz1zPzGOcIqMA0GCSqGSIb3DQEBBQUAMC0xDTALBgNVBAoTBE5FTEgx HDAaBgNVBAMTE3NwLWF1dGgubmljZS5vcmcudWswHhcNMTYxMDE3MTQxODAyWhcNMjYxMDE1MTQx ODAyWjAtMQ0wCwYDVQQKEwRORUxIMRwwGgYDVQQDExNzcC1hdXRoLm5pY2Uub3JnLnVrMIIBIjAN BgkqhkiG9w0BAQEFAAOCAQ8AMIIBCgKCAQEA4Y3iP61BpFPRO7Jp/PP1ArrdaETG+gi3AYGuW4rM sLydI+de/Mw7UP2eGkfLRGNZFfgaLq91L8kJyBg5tiA7N4FvU59kGfVXIi2+ISSIRbVYnh3zkaq1 XB0WBrNzz+pMd6hY4SmiRLzEa00EsWzTwoK/wb9z4hWOzCsgTE11oveaANyKSZARTBZUoBLe1vNY VwOqlry5ELrBKOUEtuPhty3YX1aEjTYkzRuNV4oUNfP1PloyGPFTS1HVw2FEpLbNBBxAgCwxRJGC BKOFRbE1HcVnbOmaNbTGSVsrGHXDhPAgYLIOKJGeZjNeCmG7QGwb1d+vN8AqBXlLROKRSoQncwID AQABo4GPMIGMMB0GA1UdDgQWBBRoAgT2QVp8kRq4P4DxVHMIZbYSxTBdBgNVHSMEVjBUgBRoAgT2 QVp8kRq4P4DxVHMIZbYSxaExpC8wLTENMAsGA1UEChMETkVMSDEcMBoGA1UEAxMTc3AtYXV0aC5u aWNlLm9yZy51a4IJAMz1zPzGOcIqMAwGA1UdEwQFMAMBAf8wDQYJKoZIhvcNAQEFBQADggEBABEj hpJxOBmCDUbjLcZir4Lh5I2EElvUGxx3XEhrSREDh0w4bE5CyTwvZmgG7ucd0jr2zUuUDZF7Wfxv X5vgxv1z+Hu9mJWxTcNJxDGfrYbkLj58O1uUyUr0xk2tg096UwNtIxFhG0dIjGPPvQFRxm7oOaTz J4/+8u8Jm8raTe2mouxa/r5sjYgzHORGiRkvyy1KbOqlwwUsGngUupj7cvliJiKDVBcALNhWpjWz /c74dg3VLjA/0j9s3OIUGu3qwt8+Tm8M0hkiuUotyeQ/Pxn203670p5W+nh9uwFwoqQd6G0gjTKC pZ4xNIsgMUqDtEkK4UjcnpYp7jMlid+DcWc= sp-auth.nice.org.uk MIIDbTCCAlWgAwIBAgIJAMz1zPzGOcIqMA0GCSqGSIb3DQEBBQUAMC0xDTALBgNVBAoTBE5FTEgx HDAaBgNVBAMTE3NwLWF1dGgubmljZS5vcmcudWswHhcNMTYxMDE3MTQxODAyWhcNMjYxMDE1MTQx ODAyWjAtMQ0wCwYDVQQKEwRORUxIMRwwGgYDVQQDExNzcC1hdXRoLm5pY2Uub3JnLnVrMIIBIjAN BgkqhkiG9w0BAQEFAAOCAQ8AMIIBCgKCAQEA4Y3iP61BpFPRO7Jp/PP1ArrdaETG+gi3AYGuW4rM sLydI+de/Mw7UP2eGkfLRGNZFfgaLq91L8kJyBg5tiA7N4FvU59kGfVXIi2+ISSIRbVYnh3zkaq1 XB0WBrNzz+pMd6hY4SmiRLzEa00EsWzTwoK/wb9z4hWOzCsgTE11oveaANyKSZARTBZUoBLe1vNY VwOqlry5ELrBKOUEtuPhty3YX1aEjTYkzRuNV4oUNfP1PloyGPFTS1HVw2FEpLbNBBxAgCwxRJGC BKOFRbE1HcVnbOmaNbTGSVsrGHXDhPAgYLIOKJGeZjNeCmG7QGwb1d+vN8AqBXlLROKRSoQncwID AQABo4GPMIGMMB0GA1UdDgQWBBRoAgT2QVp8kRq4P4DxVHMIZbYSxTBdBgNVHSMEVjBUgBRoAgT2 QVp8kRq4P4DxVHMIZbYSxaExpC8wLTENMAsGA1UEChMETkVMSDEcMBoGA1UEAxMTc3AtYXV0aC5u aWNlLm9yZy51a4IJAMz1zPzGOcIqMAwGA1UdEwQFMAMBAf8wDQYJKoZIhvcNAQEFBQADggEBABEj hpJxOBmCDUbjLcZir4Lh5I2EElvUGxx3XEhrSREDh0w4bE5CyTwvZmgG7ucd0jr2zUuUDZF7Wfxv X5vgxv1z+Hu9mJWxTcNJxDGfrYbkLj58O1uUyUr0xk2tg096UwNtIxFhG0dIjGPPvQFRxm7oOaTz J4/+8u8Jm8raTe2mouxa/r5sjYgzHORGiRkvyy1KbOqlwwUsGngUupj7cvliJiKDVBcALNhWpjWz /c74dg3VLjA/0j9s3OIUGu3qwt8+Tm8M0hkiuUotyeQ/Pxn203670p5W+nh9uwFwoqQd6G0gjTKC pZ4xNIsgMUqDtEkK4UjcnpYp7jMlid+DcWc=