S. Karger AG karger.ch http://unspecified Leading biomedical publisher of international specialty journals and books covering basic and clinical research subjects across the medical spectrum and related scientific areas. www.karger.com http://www.karger.com data:image/png;base64,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 Public www.karger.com MIIDFDCCAfygAwIBAgIJAIcP5l5M0JUtMA0GCSqGSIb3DQEBBQUAMBkxFzAVBgNVBAMTDnd3dy5r YXJnZXIuY29tMB4XDTE1MDUyMjA5MzAyNFoXDTE4MDUyMjA5MzAyNFowGTEXMBUGA1UEAxMOd3d3 Lmthcmdlci5jb20wggEiMA0GCSqGSIb3DQEBAQUAA4IBDwAwggEKAoIBAQCw4obBIw1EOG4VMPuU vNgbiAwUgTh6sGHvz81LPsB3yE2thixSIMxj18+TsDtesVllLJOgTROLMa3XRFlUIUcI7bm4Lv9l rwru3eEJKRKEWSO0syYhFiWdo5G10W7RaNJ5KhNmROo9PUqTIoItJXPGPWzRiRY0gXpzZTJTatzJ eh7UsEO5O2WIQV1v9WXk38q0CeYH72eI7vqXQJMsv6OXr2X2xCwFfpl1LoQxMAao9tGgSr+/Pyo1 wWEZiy/GNZX6gK+QIzQhAd9SltSC9wdRt0DMwanXcUxkTFXtSTDSudIBFGbD1AkkRllVucmoUqWm zut/wgzD0L8GNzHVqqXtAgMBAAGjXzBdMDwGA1UdEQQ1MDOCDnd3dy5rYXJnZXIuY29thiFodHRw czovL3d3dy5rYXJnZXIuY29tL3NoaWJib2xldGgwHQYDVR0OBBYEFNMyL7o+N69sGXXRJMn4O24/ yKZdMA0GCSqGSIb3DQEBBQUAA4IBAQBCSvw1+tIAUZSxTqarmKVxUJi5DZeDV3aqRQq0IJWjIljm Yj+UfPafK+/7llfev3DK+gQ2G4EIuUToLxxzQEtwpcaebr91WQwxMYYixaAl38nSaNYMY7P18r+Q mB6tYVLN+U1qmgb1FViFGb3HlFJsNUjbSXMOmHYZ6Fs+g2LKryFT3ezv0o16/Z9iuT6NnJsi5UAH RiIKAa9BnvRMIogQaJChPwkORUqIEz6GCAf3HXw/Ds2P04M1qKmFCc7jKOnls4+t+QmcmxilUL72 Hf+dbbB6iCpRLPnaWUxwzrVkL5vEaGHCDVmF3rcGxr9Zgf8PmN55LOJrZyh7DG4MCL+F www.karger.com MIIDFDCCAfygAwIBAgIJAIcP5l5M0JUtMA0GCSqGSIb3DQEBBQUAMBkxFzAVBgNVBAMTDnd3dy5r YXJnZXIuY29tMB4XDTE1MDUyMjA5MzAyNFoXDTE4MDUyMjA5MzAyNFowGTEXMBUGA1UEAxMOd3d3 Lmthcmdlci5jb20wggEiMA0GCSqGSIb3DQEBAQUAA4IBDwAwggEKAoIBAQCw4obBIw1EOG4VMPuU vNgbiAwUgTh6sGHvz81LPsB3yE2thixSIMxj18+TsDtesVllLJOgTROLMa3XRFlUIUcI7bm4Lv9l rwru3eEJKRKEWSO0syYhFiWdo5G10W7RaNJ5KhNmROo9PUqTIoItJXPGPWzRiRY0gXpzZTJTatzJ eh7UsEO5O2WIQV1v9WXk38q0CeYH72eI7vqXQJMsv6OXr2X2xCwFfpl1LoQxMAao9tGgSr+/Pyo1 wWEZiy/GNZX6gK+QIzQhAd9SltSC9wdRt0DMwanXcUxkTFXtSTDSudIBFGbD1AkkRllVucmoUqWm zut/wgzD0L8GNzHVqqXtAgMBAAGjXzBdMDwGA1UdEQQ1MDOCDnd3dy5rYXJnZXIuY29thiFodHRw czovL3d3dy5rYXJnZXIuY29tL3NoaWJib2xldGgwHQYDVR0OBBYEFNMyL7o+N69sGXXRJMn4O24/ yKZdMA0GCSqGSIb3DQEBBQUAA4IBAQBCSvw1+tIAUZSxTqarmKVxUJi5DZeDV3aqRQq0IJWjIljm Yj+UfPafK+/7llfev3DK+gQ2G4EIuUToLxxzQEtwpcaebr91WQwxMYYixaAl38nSaNYMY7P18r+Q mB6tYVLN+U1qmgb1FViFGb3HlFJsNUjbSXMOmHYZ6Fs+g2LKryFT3ezv0o16/Z9iuT6NnJsi5UAH RiIKAa9BnvRMIogQaJChPwkORUqIEz6GCAf3HXw/Ds2P04M1qKmFCc7jKOnls4+t+QmcmxilUL72 Hf+dbbB6iCpRLPnaWUxwzrVkL5vEaGHCDVmF3rcGxr9Zgf8PmN55LOJrZyh7DG4MCL+F